Cold sore



Definition

Cold sores are small red blisters, filled with clear fluid, that form on the lip and around the mouth. Rarely, they form on the roof of the mouth. Cold sores are caused by the herpes simplex virus type 1 (HSV-1), which lives inside nerve tissue. Despite their name, cold sores have nothing to do with colds. The herpes simplex virus type 1 should not be confused with the herpes simplex virus type 2 (HSV-2), which most often causes genital herpes.

Description

There are eight different kinds of human herpes viruses. Only two of these, herpes simplex types 1 and 2, can cause cold sores. It is commonly believed that herpes simplex virus type 1 infects above the waist and herpes simplex virus type 2 infects below the waist. This is not true. Both herpes virus type 1 and type 2 can cause herpes lesions on the lips or genitals, but recurrent cold sores are almost always type 1.

The sores can appear within days or weeks or even years following the first exposure to the virus. The first time symptoms appear they are usually more intense than later outbreaks. For example, some children experience more pain at the blister site or even flu-like symptoms, including swollen glands, fever , or sore throat . Medical names for cold sores include oral herpes, labial herpes, herpes labialis, and herpes febrilis.

Transmission

Herpes simplex virus is transmitted by infected body fluids (such as saliva) when they contact breaks in another person's skin or mucous membranes. Newborns may become infected during delivery through an infected birth canal. HSV-1 can be passed to children by parents, nurses, and caregivers who fail to practice careful hand washing. Children with burns , eczema, or diaper rash or those who are immunosuppressed are highly susceptible to the herpes virus.

VIRUS VERSUS BACTERIA Viruses behave differently than bacteria. While bacteria are independent and can reproduce on their own, viruses enter human cells and force them to make more viruses. The infected human cell dies and releases thousands of new viruses. The cell death and resulting tissue damage causes the cold sores. In addition, the herpes virus can infect a cell, and instead of making the cell produce new viruses, it hides inside the cell and waits. The herpes virus hides in the nervous system. This action is called latency. A latent virus can wait inside the nervous system for days, months, or even years. At some future time, the virus "awakens" and causes the cell to produce thousands of new viruses that cause an active infection.

Latent and active infection is understood by considering the cold sore cycle. The first infection is the primary infection. The primary infection is controlled by the body's immune system and the sores heal. Between active infections, the virus is latent. At some point in the future, latent viruses become activated and once again cause sores or recurrent infections. Although it is unknown what triggers latent virus to activate, several conditions bring on infections. These include stress, illness, fever, fatigue, exposure to sunlight, menstruation , and diet.

Demographics

The herpes simplex virus is widespread in children. Thirty-five percent of five-year olds carry HSV-1 antibodies. A primary infection commonly occurs by the time a child reaches age five. These viral infections are more common in lower socioeconomic groups.

Nearly 80 percent of the general population carry the herpes simplex virus that causes cold sores, and 60 million have outbreaks once or more in a year. Most infants and children harbor the herpes virus before age ten. Interestingly enough, only 20 percent to 25 percent of those carrying the virus ever gets symptoms (break out in cold sores).

Causes and symptoms

While anyone can have the herpes virus infection, not everyone will show symptoms. The first symptoms of herpes occur within two to 20 days after contact with an infected person. Symptoms of the primary infection are usually more severe than those of recurrent infections. The primary infection can cause symptoms like other viral infections, including fatigue, headache , fever, and swollen lymph nodes in the neck.

Typically, 50 to 80 percent of children with oral herpes experience a prodrome (symptoms of oncoming disease) of pain, burning, itching , or tingling at the site where blisters will form. This prodrome stage may last a few hours or one to two days. The herpes infection prodrome occurs in both the primary infection and recurrent infections.

In 95 percent of the patients with cold sores, the blisters occur at the outer edge of the lips, which is called the vermillion border. Less often, blisters form on the nose, chin, or cheek. Following the prodrome, the disease process is rapid. First, small red bumps appear. These quickly form fluid-filled blisters.

Causes of cold sores in children

Infants are most likely to get a cold sore because someone with an active virus kisses them. The cause can even be a kiss from someone who did not have a visible sore but had the virus in his or her saliva. A baby may also get the herpes virus passing through the birth canal if the mother has genital herpes.

Once a child gets the virus, it stays in his body permanently, hiding in nerve cells near the ear. In some children, the virus lies dormant and never causes harm. In others, it periodically wakes up and triggers cold sores. Nobody knows what stirs the virus into action, but stress, fever, colds, and sunburn encourage outbreaks. Rich foods such as chocolate, food allergies , or hormonal changes may also cause outbreaks in children and adolescents.

Symptoms of cold sores in infants

The first symptoms of cold sores in infants are swollen gums and sore mouth. A few days later, there is a cluster of small blisters on or near the lips that turn into a shallow, painful sore. The breakout is often accompanied with fever and swollen lymph glands in the neck. In a few days the sore will crust and slowly disappear. The whole flare-up lasts about seven to ten days. The next time the infant has an outbreak the blister is the first symptom, not the swollen gums and painful mouth. If not treated, recurring outbreaks may last longer.

Stages of cold sores in children and adolescents

Cold sores, untreated, can last up to 14 days. Children often feel the tingling at the site before the sore appears. Parents should begin the treatment at the first sign of tingling or redness, which can reduce the time to two to four days. Beginning treatment after the blister appears can also significantly reduce the time and degree of pain. The following describes the stages of a cold sore:

  • Day 1: Prodrome (tingle) stage: Before a blister appears, the child usually feels a tingling, itching, or burning sensation beneath the skin, usually around the mouth or the base of the nose. This is the best time to start treatment.
  • Days 2 to 3: The blister or blisters appear. Children usually have one or several blisters on or around the moth, most often at the border of the lip and the skin on the face. Cold sores occasionally occur on the roof of the mouth.
  • Day 4: Ulcer or weeping stage: The blister opens, revealing a reddish area. The child is most contagious and in the most pain at this point.
  • Days 5 to 8: Crusting stage: The blisters dry up, and a crust forms which is yellow or brown in color. Children should be told not to pick at this crust.
  • Days 9 to 14: Healing stage: A series of scabs form over the sore, each smaller than the previous one until the cold sore is healed.

When to call the doctor

The HSV-1 virus can cause ocular herpes, a serious eye infection affecting the cornea (the clear window) of the eye, which can threaten vision and needs immediate medical attention and treatment. When a baby or child has a cold sore, parents should do all they can to keep them from touching their eyes. If a painful sore appears on the child's eyelid, eye surface, or on the end of his nose, call the pediatrician right away. The child may need antiviral drugs to keep the infection from scarring the cornea. Ocular herpes can weaken vision and even cause blindness.

Some children have a serious primary (first episode) herpes infection called gingivostomatitis, which causes fever, swollen lymph glands, and several blisters inside the mouth and on the lips and tongue that may form large, open sores. These painful sores may last up to three weeks and can make eating and drinking difficult. Because of this problem, young children with gingivostomatitis are at risk for dehydration . Children with this condition should be seen by a doctor.

Most infants have protection for at least six months from HSV-1 by antibodies they received from their mothers. But if a newborn gets a cold sore, the pediatrician should be called right away.

If the immune system of children is compromised because of cancer treatment or AIDS , they could have more serious problems with the herpes virus. Parents should let the doctor know if these health conditions exist.

Children with a history of frequent herpes flare-ups who spend time skiing or on the beach should call a doctor for a prescription for starting oral anti-herpes medication (pills) before such outings and then using sunscreen while they are outside. These precautions can prevent most outbreaks.

Diagnosis

Cold sores are diagnosed by review of symptoms, physical examination, and history. The diagnosis is confirmed by various viral tests. A Tzanck or Papanicolau smear may be done. A positive smear cannot distinguish between varicella zoster virus and HSV-1, and a negative smear does not rule out HSV infection. Tissue culture provides a more reliable method of diagnosis. Cells killed by the herpes virus have a certain appearance under the microscope. Laboratory blood test looks for the virus or to confirm the presence of antibodies that fight the virus.

Approximately 85 percent of active herpes infections are without symptoms. When the symptoms do appear, they have the following sequence:

  • burning, itching, or tingling at the site before the sore appears
  • clusters of fluid-filled vesicles ulcerate, dry, and crust
  • lesions dry and crust within seven to ten days
  • usually one or two lesions present on the lips, tongue, gingival, or buccal mucosa
  • puritis (itching) and pain

Treatment

There is no cure for herpes virus infections. Antiviral drugs are available that have some effect on lessening the symptoms and decreasing the length of herpes outbreaks. There is evidence that some may also prevent future outbreaks. These antiviral drugs work by interfering with the reproduction of the viruses and are most effective when taken as early in the infection as possible. For the best results, drug treatment should begin during the prodrome stage before blisters are visible. Depending on the length of the outbreak, drug treatment could continue for up to ten days.

Antiviral pills such as acyclovir (Zovirax), famciclovir, (Famvir), and valacyclovir (Valtrex) can cancel an outbreak and help prevent recurrent outbreaks. Acyclovir (Zovirax) is the drug of choice for herpes infection and can be given intravenously or taken by mouth. A liquid form for children is also available. Acyclovir is effective in treating both the primary infection and recurrent outbreaks. When taken by mouth, acyclovir reduces the frequency of herpes outbreaks.

Antiviral creams Zovirax and Denavir should be applied within the first 24 hours of feeling the tingling or discomfort, before the plaster erupts. The duration of the outbreak can be shortened by a day or two. Antiviral creams are not as effective as the pills.

During an outbreak, sores should be washed once or twice a day with warm, soapy water, and gently patted dry. Over-the-counter lip products that contain the chemical phenol (such as Blistex Medicated Lip Ointment) and numbing ointments (Anbesol) help to relieve cold sores. A bandage over the sores protects them and prevents spreading the virus to other sites on the lips or face.

Close-up view of a cold sore, caused by herpes simplex virus, on a patients mouth. ( Kenneth Greer/Visuals Unlimited.)
Close-up view of a cold sore, caused by herpes simplex virus, on a patient's mouth.
(© Kenneth Greer/Visuals Unlimited.)

Acetaminophen (Tylenol) or ibuprofen (Motrin, Advil) may be necessary to reduce pain and fever.

Alternative treatment

Cold sores in infants and children will go away on their own, but there are measures that will help the child feel better:

  • To ease the pain, apply ice to the sore, or if the doctor approves, give the baby a mild pain reliever, such as ibuprofen or acetaminophen. (Do not give aspirin to a baby; it could trigger Reye's syndrome. This is a rare but potentially life-threatening illness.) Choices for pain relief include medication, ointments, or mouth rinses recommended by the pediatrician. Parents may also use Oragel, an ointment often used for canker sores or teething.
  • Avoid giving the child spicy, salty, or sour foods, and foods with acid (oranges and grapefruits), which can irritate the open sore.
  • Apply a water-based zinc ointment such as Desitin. It helps dry out the sore so it can heal faster.
  • Extra sleep and plenty of liquids to drink can help.

Adolescents can learn to manage their own outbreaks. They can take the following steps:

  • Use over-the-counter pain relievers, such as acetaminophen (Tylenol) or ibuprofen (Motrin, Advil).
  • Avoid squeezing or picking the blister.
  • Apply ice to ease the pain.
  • Acidophilus pills may be helpful in treating cold sores. L-lysine is an amino acid widely advertised to treat cold sores. Conflicting medical opinions exist about its effectiveness.

Nutritional concerns

If children are prone to recurrent viral infections, parents should review their eating habits. The children should avoid foods and drinks that are proven suppressors of immunity (foods high in sugar, caffeine , and alcohol content) and have regular meals with plenty of fresh vegetables and fruits and whole-grain products. Some foods may be increased or reduced for specific types of viral infections. For herpes, foods containing the amino acid arginine (nuts and seeds) need to be reduced, and those containing the amino acid lysine (yogurt and cottage cheese) need to be increased. Immune system health in children can also benefit from a wide range of vitamins and minerals as nutritional supplements. Vitamin B complex and vitamins A, C, and E are the most important supplements.

Prognosis

Anyone can become infected with the herpes virus. Once infected, the virus remains latent in the body for life. It lives in nerve cells where the immune system cannot find it. The herpes virus lies dormant in the nerves of the face and is reactivated by sunburn, a recent viral illness (cold or flu), and periods of stress. Cold sores spread from person to person by direct skin-to-skin contact.

The highest risk for spreading the virus is the time period beginning with the blisters and ending with scab formation. However, infected people need not have visible blisters to spread the infection since the virus may be present in the saliva without obvious oral lesions.

Most children experience fewer than two recurrent outbreaks of cold sores each year; some have frequent outbreaks and others never experience outbreaks. Most blisters form in the same area each time and are triggered by the same reasons (such as stress, sun exposure, etc.).

Prevention

Cold sores are contagious. As of 2004 there were no herpes vaccines available, although herpes vaccines were in research and development. Avoiding close contact with people shedding the virus is the best way to prevent primary herpes. Several practices can reduce reoccurring cold sores and the spread of virus:

  • Parents should teach children not to share drinks, food, or eating utensils, and not to exchange kisses with someone with mouth sores.
  • When parents have an outbreak, they should avoid kissing their children (and other adults).
  • Parents should be watchful of infected children and not allow them to share toys that may be put into the mouth. Toys that have been in the child's mouth should be disinfected before other children play with them.
  • Parents should be especially careful with infants; they should not kiss the eyes or lips of a baby who is under six months old. The child's eyes and genitals are particularly susceptible to the herpes virus. They should keep the child from picking at a cold sore as much as possible.
  • To keep from spreading the infection to other parts of the child's body or giving the virus to someone else, parents and caregivers should wash their hands and the child's hands often, especially after feedings and diaper changes.
  • The child should be protected from the sun, since exposure to sunlight can trigger an outbreak. If the child is outside on a sunny day, generously apply sunscreen and lip balm that contains sun block before prolonged exposure to the sun. Sun block should be used during both winter and summer months, to help prevent cold cores. Wearing a hat with a large brim is also helpful.
  • Parents should wear gloves when applying ointment to a child's sore. They should remove gloves and wash hands before and after changing diapers.
  • Antibiotic ointments may be used to treat secondary bacterial infection of lesions. Parent should avoid using steroid creams or gels on a suspected herpes infection because these agents could make the infection worse.
  • Parents should maintain good general health. A healthy diet, plenty of sleep, and exercise help to minimize the chance of getting a cold or the flu, which may bring on cold sores. Also, good general health keeps the immune system strong; this helps to keep the virus in check and prevents outbreaks.

Parental concerns

The child with a herpes infection is usually miserable and needs generous cuddling and comfort in spite of the infection. Parents of children who get cold sores should be aware of early symptoms and be ready to treat the sore in the first couple days. They should also keep in mind the prevention tips mentioned above. Parents should call the child's pediatrician if the child has not had a cold sore before, especially in the case of babies.

KEY TERMS

Antiviral drug —A medication that can destroy viruses and help treat illnesses caused by them.

Contagious —The movement of disease between people. All contagious disease is infectious, but not all infections are contagious.

Herpetic gingivostomatitis —A severe oral infection that affects children under five years of age; vesicles and ulcerations, edematous throat, enlarged painful cervical lymph nodes occur; chills, fever, malaise, bed breath, and drooling.

Latent virus —A nonactive virus that is in a dormant state within a cell. The herpes virus is latent in the nervous system.

Oral lesions —A single infected sore in the skin around the mouth or mucus membrane inside of the oral cavity.

Prodrome —Early symptoms that warn of the beginning of disease. For example, the herpes prodrome consists of pain, burning, tingling, or itching at a site before blisters are visible while the migraine prodrome consists of visual disturbances.

Recurrence —The return of an active infection following a period of latency.

Reye's syndrome —A serious, life-threatening illness in children, usually developing after a bout of flu or chickenpox, and often associated with the use of aspirin. Symptoms include uncontrollable vomiting, often with lethargy, memory loss, disorientation, or delirium. Swelling of the brain may cause seizures, coma, and in severe cases, death.

Secretion —A substance, such as saliva or mucus, that is produced and given off by a cell or a gland.

Resources

BOOKS

Health and Healing the Natural Way: Energize Your Life. Pleasantville, New York: The Reader's Digest Association, Inc., 2000.

Parker, Philip M., et al. Cold Sores: A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References. Boulder, CO: netLibrary, 2003.

PERIODICALS

Novatnack, Ellen, and Steven Shchweon. "Herpes: A bigger problem than you think." RNMagazine 65 (June 2002):31-37.

WEB SITES

"Herpes labialis (oral Herpes simplex)." MedlinePlus , July 12, 2004. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/000606.htm (accessed December 14, 2004).

Aliene S. Linwood, RN, DPA, FACHE Belinda Rowland, PhD



User Contributions:

1
hannah xuereb
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Jul 29, 2006 @ 11:11 am
my daughter is 15 months old she had coldsores come up about 3 months ago and ended up in hospital she evently got better. They have come up again been to the doctors they gave her zarvirax its been about a week her temp has gone as high as 40.2 keep giving her fluids as she is not eating i am worried as she is small for her age anyway do u have any suggestions?
2
Dawn
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May 6, 2008 @ 8:20 pm
My 4 1/2 year old son has recently complained of his mouth hurting, yet there was nothing visually there. The day care provider called and informed me that he has a "cold sore". Now, i don't know anyone that has a cold sore at this time, and he has not been around kissing anyone that i am aware of. I was just wondering if cold sores can be inherited?? I only ask this because my son's father has a history of cold sore/ canker sore breakouts and want to know if i have to be prepared for my son to have them as well.
3
michelle allison
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Mar 29, 2017 @ 3:03 am
I WAS CURED FROM HERPES WITH HERBS AND ROOTS
michelle allison is my name,i am from USA. I am here to give
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4
john miley
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Mar 29, 2017 @ 4:04 am
I'm John Miley, an army of the United States.
I want to tell you all about Dr Akpan the herbal doctor that was able to cure me from my Herpes Virus with his herbal medicine. I have been a Herpes patient for almost 8 months now i noticed it on time while on duty and have tried different methods of treatment to ensure that I am cured of this terrible disease, but none worked for me, so I had to leave everything to God to handle and quit my duty as I was encountering some symptoms yet I felt so sad and desperate as I was losing almost everything due to my illness, A few months ago while I was searching the internet I saw different recommendation about Dr Akpan on how he have been using his herbal Medicine to treat and cure people, these people advice we contact Dr Akpan for any problem that would help immediately, I contacted Dr Akpan and I told him how I got his contact and also about my disease, after some time Dr Akpan told me to have faith that he would prepare for me a medication of herbal herbs, he told me I would take this medicine for a few weeks so and he did it as i gladly followed his instructions as i needed this to go, so my after all the process and everything Dr Akpan actually sent me the medicine, I took it as I was directed by Dr Akpan, after a few weeks passed, while on Dr Akpan medication I began to experience changes in my body, I had to call my doctor at the barrack clinic for some blood test after test my hospital doctor told me that I was no longer with the Herpes virus and my blood is pretty good, well today i am Herpes Free and i want everyone to know that there is a cure for Herpes for those who will contact Dr Akpan after reading my post, you can contact Dr Akpan on his email AKPANHERBALHELP@GMAIL.COM call or whatsApp him on Mobile: +2348143502763
5
frank sammy
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Mar 29, 2017 @ 4:04 am
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6
SARAH SHENNA
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Mar 29, 2017 @ 5:05 am
I am here to give my testimony about Dr BEN who helped m.. i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS) by Dr BEN, i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Dr BEN cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took for just 2 weeks and it seriously worked for me, my HERPES result came out negative. I am so happy as i am sharing this testimony. My advice to you all who thinks that their is no cure for herpes that is Not true just contact him and get cure from Dr BEN healing spell cure of all kinds of sickness you may have. Remember delay in treatment leads to death.. email him benherbaltemple@gmail.com or call him +1(310) 220-0075.
7
enuice mabel
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Mar 29, 2017 @ 5:05 am
God bless Dr ihibor for his marvelous work in my life, I was diagnosed of HERPES since 2014 and I was taking my medications, I wasn't satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr ihibor , how he cured HERPES DIABETES and CANCER with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine through UPS SPEED POST. I took the medicine as prescribed by him and 14 days later i was cured from HERPES, Dr ihibor truly you are great, do you need his help also? Why don't you contact him through his email address;drihiborherbalhome@gmail.com or whatsapp him on +2349050141449
8
Report this comment as inappropriate
Mar 29, 2017 @ 7:07 am
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9
john miley
Report this comment as inappropriate
Mar 29, 2017 @ 7:07 am
I'm John Miley, an army of the United States.
I want to tell you all about Dr Akpan the herbal doctor that was able to cure me from my Herpes Virus with his herbal medicine. I have been a Herpes patient for almost 8 months now i noticed it on time while on duty and have tried different methods of treatment to ensure that I am cured of this terrible disease, but none worked for me, so I had to leave everything to God to handle and quit my duty as I was encountering some symptoms yet I felt so sad and desperate as I was losing almost everything due to my illness, A few months ago while I was searching the internet I saw different recommendation about Dr Akpan on how he have been using his herbal Medicine to treat and cure people, these people advice we contact Dr Akpan for any problem that would help immediately, I contacted Dr Akpan and I told him how I got his contact and also about my disease, after some time Dr Akpan told me to have faith that he would prepare for me a medication of herbal herbs, he told me I would take this medicine for a few weeks so and he did it as i gladly followed his instructions as i needed this to go, so my after all the process and everything Dr Akpan actually sent me the medicine, I took it as I was directed by Dr Akpan, after a few weeks passed, while on Dr Akpan medication I began to experience changes in my body, I had to call my doctor at the barrack clinic for some blood test after test my hospital doctor told me that I was no longer with the Herpes virus and my blood is pretty good, well today i am Herpes Free and i want everyone to know that there is a cure for Herpes for those who will contact Dr Akpan after reading my post, you can contact Dr Akpan on his email AKPANHERBALHELP@GMAIL.COM call or whatsApp him on Mobile: +2348143502763
10
marria gotch
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Mar 29, 2017 @ 9:09 am
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11
FRANKS
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Mar 29, 2017 @ 5:17 pm
My name is ALEX JENNY, and i want to thank Dr. Osagie for the herbal remedy he gave to me, i was suffering from HIV/ADS for so many years, but to God be the glory that i am healed with the herbal medicine that Dr. Osagie gave to me when i contacted him. i want to use this medium to tell everyone that the solution to our sickness has come, so i will like you to contact this great healer on his email address:(drosagiesolutiontemple@gmail.com OR
DROSAGIESOULTIONTEMPLE@YAHOO.COM
) or whatsapp: +2347030465649, with him all your pains will be gone, i am really happy today that i am cured of HIV/ADS, i am now free from HIV/ADS VIRUS after the use of his herbal medicine. Once more i say a big thank you Dr. Osagie for healing me, i say may God continue to bless you abundantly and give you more power to keep helping those that want your help in their lives. contact him now on his email: (drosagiesolutiontemple@gmail.com OR
DROSAGIESOULTIONTEMPLE@YAHOO.COM
) or His Whatsapp number: +2347030465649... Dr osagie has also cured my friend Vivan from HERPES DISEASE, so if you are infected with HERPES DISEASE kindly contact Dr osagie right now..
12
FRANKS
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Mar 29, 2017 @ 5:17 pm
My name is ALEX JENNY, and i want to thank Dr. Osagie for the herbal remedy he gave to me, i was suffering from HIV/ADS for so many years, but to God be the glory that i am healed with the herbal medicine that Dr. Osagie gave to me when i contacted him. i want to use this medium to tell everyone that the solution to our sickness has come, so i will like you to contact this great healer on his email address:(drosagiesolutiontemple@gmail.com OR
DROSAGIESOULTIONTEMPLE@YAHOO.COM
) or whatsapp: +2347030465649, with him all your pains will be gone, i am really happy today that i am cured of HIV/ADS, i am now free from HIV/ADS VIRUS after the use of his herbal medicine. Once more i say a big thank you Dr. Osagie for healing me, i say may God continue to bless you abundantly and give you more power to keep helping those that want your help in their lives. contact him now on his email: (drosagiesolutiontemple@gmail.com OR
DROSAGIESOULTIONTEMPLE@YAHOO.COM
) or His Whatsapp number: +2347030465649... Dr osagie has also cured my friend Vivan from HERPES DISEASE, so if you are infected with HERPES DISEASE kindly contact Dr osagie right now..
13
mrs marian
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Mar 29, 2017 @ 5:17 pm
Its a pleasure for me to write this testimony about this wonderful thing
that happened to me last week on how i got my HIV aids cured, i have been
reading so-many post of some people who were cured of HIV, but i never
believed them, I was hurt and depressed so I was too curious and wanted to
try dr.okosodo then i contacted him on his email on drokosodohealingalter@gmail.com when i contact him, he assured me 100% that he will heal me, i pleaded with him to
help me out, its a great success that he healed just as he promised, he
told me that in three days time that i should go and check on my HIV
status, I was floored that when i went to the hospital to check of my
status that i was HIV negative, i never thought possible that dr. Okosodo
can do miracles, i never really believed in magic but I played along with a
little hope and faith and after everything but dr okosodo changed my
life and made me a true believer you can contact him on
drokosodohealingalter@gmail.com or whattsapp Number: +2349074505296 or drokosodohealingalter@outlook.com so he can help you out. you can as well contact me with my email: mrsmarian11@gmail.com to also know more information. he said that he is also specialize on the following diseases: HERPES, HIV, ALS, HPV, DIABETES, HEPATITIS B, CANCER, And Bring Back Yours Ex back.
14
ANABEL
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Mar 29, 2017 @ 6:18 pm
Hi Friends i am so glad to writing this article today to tell the world how Dr Unuareghe cured my HSV VIRUS,i have been detected with HSV-1 AND HSV-2 since five years ago, ever since then my life has been in complete bizarre and agony,i have used so many drugs that was prescribed to me by several doctors,but it didn’t cure my HSV VIRUS neither did it reduce the pain,until a certain i was checking for solution in the internet,then miraculously came across Dr Unuareghe the powerful herbalist that cure numerous individuals HSV-1 AND HSV-2 INFECTION,then i contacted his email: dr.unuareghecuringhome@gmail.com i explained everything to him and prepared a cure that cure my HSV-1 AND HSV-2 disease totally after receiving his herbal medicine, so my friends viewers why wait and be suffer when there is someone like Dr Unuareghe that can cure any disease HIV/ CANCER/ HEPATITIS B VIRUS, you can contact his via:dr.unuareghecuringhome@gmail.com or watsapp +2349067894643
15
vivian petrov
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Mar 29, 2017 @ 8:20 pm
ALL THANKS TO DR SHOKPIKAN WITH HIS HERB, I WAS CURED FROM A TERRIBLE TINNITUS.
.It Is my pleasure to comment on this site and i thank the admin of this site for his/her great work so far. I really don’t know how to thank DR SHOKPIKAN for helping me get cured for over 20 year of suffering from a terrible tinnitus, my tinnitus started when i turns 10 we all thought is going to end one day but even get worse as days went by,i have tried all western drugs prescribed by doctors but to no avail i lost total concentration, even at night i screams even more because the sounds become louder because everywhere is quiet. i came across DR SHOKPIKAN contact through a headline news on internet about how DR SHOKPIKAN have help so many people to get cured of tinnitus and so many other with similar body problem ,i contacted him and he told me how to get his herb,few day later he sent me the herbal portion which i took every morning for 14 days, and his medicine was able to restore me back to normal and now am very okay without any side effects whatsoever If you have Tinnitus, you can contact him on his email address dr.shokpikan@gmail.com for help
16
CASEY
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Mar 29, 2017 @ 11:23 pm
THE ONLY TRUE HERBALIST WITH TEST RESULTS(PROVE) OF PEOPLE HE HAVE CURED OF MANY INFECTIONS AND DISEASES,AFTER CONTACTING 3 HERBALIST ONLINE,ONLY HIM COULD CURE ME OF 2 YEARS GENITAL HERPES...HE IS REAL AND GENUINE

HOW I GOT RID OF MY 2 YEARS GENITAL HERPES WITHIN 7 DAYS,GOD IS AWESOME!
THIS IS REAL,PLEASE DON'T IGNORE.Call/Text me via; +1(614)230-0384

HIS WEBSITE;https://doctorsambolablog.wordpress.com

I caught genital herpes from my Ex Husband in 2015,he never told me about the virus. I had it for 2 years with so many outbreak,and it affected my life.. People think herpes is really a minor skin irritation herpes has a long term effects on health. The stigma attached to this virus by ignorant people is ridiculous. Most people have herpes in one form or another,i was first taking Antiviral medicines, such as acyclovir(Zovirax), famciclovir (Famvir), and valacyclovir (Valtrex), are recommended for treating primary genital herpes outbreaks. This medicine can be taken when an outbreak occurs. It can also be taken every day to help prevent outbreaks,it is not a total cure... I will like to tell everyone who is reading this my testimony on how i get rid of my genital herpes.I was reading a comment on the internet,and i saw a testimony posted by a young lady from USA that she got rid of her herpes with the help of doctor SAMBOLA,a Traditional Herbalist.So i was so happy when i saw that post,that his herbal medication Cure the virus totally.I quickly copied the herbal doctor email address and i email him within 30 minutes he respond to my mail.I explain things to him he told me not to worry that i should fill his herbal form which i did..The next day he told me that he has prepare the herbal medicine,that i should send him my address that he want to sent his HERBAL MEDICINE to me via DHL or FedEx that was how i got the herbal medication and i use it as i was instructed.After a week i went to see a Medical Doctor who confirmed my herpes was no more.When some of my friend who has herpes saw me they were surprise and i also introduce them to the man and they are also cure from the same Genital herpes today.I also refer my cousin to the same herbalist who was having HIV and today she is fully cure...If you have Genital or Oral herpes or any kind of Diseases and infections,kindly contact HERBALIST SAMBOLA via this email;herbalistsambola@gmail.com OR herpesherbalcure@gmail.com/


He also have a herbal cure for Following DISEASES,this is not scam is 100% Real.

-PENIS ENLARGEMENT AND WEAK ERECTION
-VIRGINA PROBLEM
-WHOOPING COUGH
- HEPATITIS B
-FORDYCE SPOT
-ALS
-LOWER RESPIRATORY INFECTION
-LOW SPERM COUNT
-MRSA(METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
-ZIKA VIRUS
-COPD
-STROKE
-IMPOTENCE
-PILE
-HYPERTENSION
-LOW SPERM COUNT
-MENOPAUSE DISEASE
-ASTHMA
-CANCER
-BARENESS/INFERTILITY
-PCOS
-SHINGLES
-VIRAL HEPATITIS/HEPATITIS B
-FIBROID
-ASTHMA
-SICKLE CELL
-TINNITUS
-BARENESS/INFERTILITY
-DIARRHEA and so on...

Contact him today and you will have a testimony..
GOD IS TRULY GREAT..Click on the link of the Doctor that cure me of my GENITAL HERPES;https://doctorsambolablog.wordpress.com

Call/Text me via; +1(614)230-0384

Good luck.
17
CASEY
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Mar 29, 2017 @ 11:23 pm
CURE YOUR SELF FROM THAT ILLNESS TODAY,DON'T SPREAD YOUR INFECTION OR DISEASES TO OTHER INNOCENT PEOPLE OUT THERE...He don't treat diseases,He cure them.?Contact Dr Sambola today and you will have a testimony...GOD IS TRULY GREAT..Click on the link of the Doctor that cure me of my 5 years GENITAL HERPES; Herbalistsambola@gmail.com
18
Abdul Saheed
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Mar 30, 2017 @ 12:00 am
Good-news my viewers i am Rashid Ahmed, am from Dubai, Me and my entire family has been suffering for hepatitis B from birth, We have gone to all the hospitals and there wasn't any solution even our family DR confirm it to us that there is no cure for this disease but can only be control even my first child is Hepatitis B positive, till this day a friend of mine told me about this Dr Akuna who have help her to get rid of this incurable disease name Hepatitis B, That was how i give it a try, to my fullest surprise me and my entire families are now Negative of Hepatitis B even it was a surprise to my scientist Dr who graduated with PhD here in Dubai, he now direct all his Hepatitis B positive patient to this wonderful Dr Akuna who cured all diseases with herbal medicine, don't be left out contact him if you are diagnose with this same disease, after be cured he told me that he cured all manners of diseases,i am sharing this testimony both in internet and everywhere so that people who are diagnosed with kind of diseases should contact Dr Akuna via email:drakunasolutiontemple@gmail.com or what app his Mobile:+2348154625070
19
marria gotch
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Mar 30, 2017 @ 1:01 am
I did not believe is possible that HIV can be cured because i have been scammed so many times not until i came across this great man dr agbebaku who helped me at first I never believe all this comment and post about him and I was very sick because i have been infected with HIV for the past seven years,just last year I keep reading the testimony about this man named dr agbebaku they said that the man is so powerful he have cured different type of diseases, I keep monitor the post of some people about this man and I found out that he was real so i decided to give him a try I contacted him for help and he said he was going to help me get my cure that all i needed to do was to send him money to prepare the medication after which it will be sent to me via dhl service which i did to my greatest suprise the medication was sent to me he gave me instructions on how to use it that after three weeks i should go for check up at first i was shocked when the doctor told me that i was hiv negative i ask the doctor to check again and the result was the same that i was now free from hiv at of the shock i decided to come and share my testimony with you for those who think there is no cure for hiv the cure as finally come stop doubting and contact dr agbebaku via email dragbebakuspellsolutiontemple@gmail.com he will help you out you can also wattssap him via +2349053099479 he said he also as cure for DIABETICS,HERPES,INFERTILITY;ALS,ANCE PIMPUS,LUPUS VIRUS AND PENIS AND BREAST ENLARGEMENT
20
enuice mabel
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Mar 30, 2017 @ 2:02 am
God bless Dr ihibor for his marvelous work in my life, I was diagnosed of HERPES since 2014 and I was taking my medications, I wasn't satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr ihibor , how he cured HERPES DIABETES and CANCER with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine through UPS SPEED POST. I took the medicine as prescribed by him and 14 days later i was cured from HERPES, Dr ihibor truly you are great, do you need his help also? Why don't you contact him through his email address;drihiborherbalhome@gmail.com or whatsapp him on +2349050141449
21
mabeljeff
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Mar 30, 2017 @ 3:03 am
God bless Dr EKADOLA for his marvelous work in my life, I was diagnosed of HERPES since 2013 and I was taking my medications, I wasn't satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr EKADOLA, how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine through UPS SPEED POST. I took the medicine as prescribed by him and 14 days later i was cured from HERPES, Dr EKADOLA truly you are great, do you need his help also? Why don't you contact him through: (ekiadolaherbalhome@gmail.com) or you can also reach him on phone +2349057915075

DOCTOR UYI CAN AS WELL CURE THE FOLLOWING DISEASE:-

HIV/AIDS
HERPES
CANCER
ALS
STD
22
David Ronald
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Mar 30, 2017 @ 4:04 am
I want to testify a great testimony of how Dr.SABU help me,i was heartbroken because i had very ( SMALL PENIS ) not big enough and I couldn't satisfy a real lady in bed and the worse of my problems was that i cum on the sight of a ladies vagina. I battled this problems since i was teen and still couldn't get any good victory. I was online searching for guaranteed results providing products to enlarge the size of my penis when i saw a review of Dr.SABU Penis Enlargement Skills posted by so many poeple that he has help to enlargement penis,i read through the comment and emailed the contact (drsabuspelltemple@gmail.com) on it. The doctor called me some few moments later and attended to me more better than i expected. I was convinced and i made purchase of his herbal medicines for Penis Enlargement and Quick Ejaculation. The medicines was sent to me BY UPS DELEVERY and i received it at my home, i applied it as instructed and just few weeks of using the herbal medicines i got a perfect good size of penis. I now measure about 16.0 cm (8.4 inches) when flaccid and 24.3 cm (9.1 inches) when erect. Am so happy and comfortable with the new size of my penis, i feel no discomfort or whatever. Am so happy with this fast results. You too can reach Dr.SABU for same Penis Enlargement medicines on drsabuspelltemple@gmail.com or his WHATSAPP/CALLS +2347057624993 or his websites: https://drsabuspelltemple.wixsite.com/dr-sabu
23
mansonevelin
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Mar 30, 2017 @ 4:04 am
Hello, Manson evelin by name, I am testifying about Dr. Ken the
Great herbalist, who has the cure for all diseases, who cured me the
HIV disease, even if I have included it, went through the different website seen
Different testimonials about different herbalists that was like, "many people
It has the cure of HIV because people continue to suffer its consequences "
I thought about it, so I got in touch with Dr. Ken by email
I do not think much, I just wanted to give it a try, he replied.
Mail and you need some information for me, then I sent you, you prepared
Cured and shipped via UPS courier, I was told it would take 3-4 days
Before receiving the package, 3 days later I received the package and started
Take the medications prescribed by him after 7 days of taking
Medication, I went to a test, I tried the HIV NEGATIVE.
I give thanks to my faithful God. IF YOU ARE NEEDED You will be healed, put it yourself
Contact Dr. Ken in whats-app .. whats, or call +2347039225049, email it
dr.kenherbalcure@gmail.com

(THIS TYPE OF DISEASES DOCTOR KEN SPECIALIZED IN)
{1} HIV / AIDS
{2 CANCER
{3} HERPES
{4} DIABETES
(5) HEPATITIS B & C
(6 HPV
(7) V.B
(8) HERBAL PREGNANCY MEDICINE.
24
clara
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Mar 30, 2017 @ 5:05 am
I has suffered for Human papillomavirus HPV) for 2years, I was given some tablets at the hospital but I refused to take it, They said I have to be on it for life so I don't want take a drugs everyday for life. No point in taking medicine everyday when u won't get cure from it and I was advice to seek for natural herbal cure, after some time I found dr Akube is the most trustful herbalist that have herbs to cure wicked symptom's,I emailed dr Akube, for 2weeks been his patient he cured my (HPV) with his herbal. I only used his natural herbs for two weeks it was 100% cure. I'm not (HPV) patient anymore. I'm happy about it i finally got cured out of this mess been in my body for 2years. I also recommend you if you're living with (HPV) or herpes symptoms i also want you to be free contact dr akube with the email attach to my post dr.akubecuringhome@gmail.com you call his number +2349068192820

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