Hand-foot-mouth disease


Hand-foot-mouth disease is an infection of young children in which characteristic fluid-filled blisters appear on the hands, feet, and inside the mouth.


Coxsackie viruses belong to a family of viruses called enteroviruses. These viruses live in the gastrointestinal tract and are, therefore, present in feces. They can be spread easily from one person to another when poor hygiene allows the virus within the feces to be passed from person to person. After exposure to the virus, development of symptoms takes only four to six days. Hand-foot-mouth disease can occur year-round, although the largest number of cases are in summer and fall months.

An outbreak of hand-foot-mouth disease occurred in Singapore in 2000, with more than 1,000 diagnosed cases, all in children, resulting in four deaths. A smaller outbreak occurred in Malaysia in 2000. In 1998, a serious outbreak of enterovirus in Taiwan resulted in more than 1 million cases of hand-foot-and-mouth disease. Of these, there were 405 severe cases and 78 deaths, 71 of which were children younger than five years of age.

Hand-foot-mouth should not be confused with foot and mouth disease, which infects cattle but is extremely rare in humans. An outbreak of foot and mouth disease swept through Great Britain and into other parts of Europe and South America in 2001.


Hand-foot-mouth disease is very common among young children and often occurs in clusters of children who are in daycare together.

Causes and symptoms

Hand-foot-mouth disease is spread when poor hand washing after a diaper change or contact with saliva allows the virus to be passed from one child to another.

Within about four to six days of acquiring the virus, an infected child may develop a relatively low-grade fever , ranging from 99 to 102°F (37.2–38.9°C). Other symptoms include fatigue, loss of energy, decreased appetite, and a sore sensation in the mouth that may

Blisters shown on the foot a child with hand-foot-mouth disease. (Custom Medical Stock Photo, Inc.)
Blisters shown on the foot a child with hand-foot-mouth disease.
(Custom Medical Stock Photo, Inc.)
interfere with feeding. After one to two days, fluid-filled bumps (vesicles) appear on the inside of the mouth, along the surface of the tongue, on the roof of the mouth, and on the insides of the cheeks. These are tiny blisters, about 3–7 mm in diameter. Eventually, they may appear on the palms of the hands and on the soles of the feet. Occasionally, these vesicles may occur in the diaper region.

The vesicles in the mouth cause the majority of discomfort, and the child may refuse to eat or drink due to pain . This phase usually lasts for an average of a week. As long as the bumps have clear fluid within them, the disease is at its most contagious. The fluid within the vesicles contains large quantities of the causative viruses. Extra care should be taken to avoid contact with this fluid.


Diagnosis is made by most practitioners solely on the basis of the unique appearance of blisters of the mouth, hands, and feet, in a child not appearing very ill.


As of 2004, there were no treatments available to cure or decrease the duration of the disease. Medications like acetaminophen or ibuprofen may be helpful for decreasing pain and helping the child to eat and drink. It is important to try to encourage the child to take in adequate amounts of fluids, in the form of ice chips or Popsicles if other foods or liquids are too uncomfortable. There is a risk of developing dehydration .


The prognosis for a child with hand-foot-mouth disease is excellent. The child is usually completely recovered within about a week of the start of the illness.


Prevention involves careful attention to hygiene. Thorough, consistent hand-washing practices and discouraging the sharing of clothes, towels, and stuffed toys are all helpful. Virus continues to be passed in the feces for several weeks after infection, so good hygiene should be practiced long after all signs of infection have passed.


Parents should be aware of the characteristic rash of hand-foot-mouth disease and monitor their children, especially if they are in a child care setting. Good hygiene practices should be strictly followed to prevent the spread of the disease.


Enterovirus —Any of a group of viruses that primarily affect the gastrointestinal tract. The coxsackie-virus and the poliovirus are both enteroviruses.

Vesicle —A bump on the skin filled with fluid.



Abzug, Mark J. "Nonpolio Enteroviruses." In Nelson Textbook of Pediatrics. Edited by Richard E. Behrman et al. Philadelphia: Saunders Company, 2004.


Hairston, B. R. "Viral diseases of the oral mucosa." Dermatology Clinics 21 (January 2003): 17–32.

Purdon, M. "Pediatric viral skin infections." Clinical Family Practice 5 (September 2003): 589.

Sy, Man-Sun, et al. "Human Prion Diseases." Medical Clinics of North America 5 (September 2003): 557.

Wolfrey, J. "Pediatric exanthems." Clinical Family Practice 86 (May 2002): 551–571.

Rosalyn Carson-DeWitt, MD Ken R. Wells

User Contributions:

marteshia ford
This is great to know now I feel more at ease. I just found out about this disease today and im in med school well I guess u learn more and more everyday thanks because now all of my questions have been answered and once again im a happy mom thanks.

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